Zeitschrift für Bioremediation und biologischen Abbau

Abstrakt

A Two-Phase and Long-Lasting Multi-Antibacterial to Prevent Implants-Related Infections

Agata Wojcik

In clinical practise, bacterial infection and aseptic loosening pose the biggest obstacles to titanium implant placement and significantly lower the survival rate of implants. The infection peak period for implants is the first four weeks following surgery. For an implant to be successful, it is crucial to prevent bacterial adhesion and growth during the initial stages as well as to encourage subsequently occurring osteointegration. Here, using a modified layer-bylayer method and dopamine polymerization, we created a quaternary ammonium carboxymethyl chitosan, collagen, and hydroxyapatite multilayer coating on Ti substrates. HAP coating demonstrated a two-phase function and several antibacterial properties. The covalently bound QCMC showed both contact-killing and release-killing properties during the infection peak phase at the first four weeks postoperatively; the second stage involves osteogenesis [1].