OMICS Journal of Radiology

Abstrakt

Can Gemstone Spectral Imaging Accurately Determine the Concentration of Iodine Contrast: A Phantom Study

Le Wang, Bin Liu, Xing-wang Wu, Jie Wang, Wan-qin Wang, Yong Zhou, Xiao-hong Zhu, Zhang Shuai and Gao Na

Purpose: To assess the accuracy of the quantification of the iodine concentration of contrast agent using gemstone spectral imaging under static and pulsating conditions respectively. Methods: A phantom with nine test tubes containing iodine contrast in various concentrations (0.4, 0.7, 2.5, 10, 20, 30, 50 and 100 mg/ml) was scanned with gemstone spectral imaging mode of Discovery CT750 HD. All the scans were performed at static and pulsating status at gantry rotation time of 0.6 s, 0.8 s and 1.0 s respectively. Data were transferred to a work station to acquire iodine-based images, and the iodine contrast was measured within samesized regions of interest at the same level. The relation and discrepancy between measured concentrations and real concentrations of the iodine contrasts were analyzed. Results: At gantry rotation time of 0.8 s and 1.0 s, either at static status or pulsating status, the measured concentrations were significantly correlated with the real concentrations (p=0.000, r=0.999), without significant statistic difference (p>0.05). However, at gantry rotation time of 0.6 s, there was a statistically significant difference between the measured values and the real values (p<0.05), even though existed linear correlation between them (p=0.000, r=0.999). Conclusions: Gemstone spectral imaging is a reliable method to accurately quantify the concentration of iodine contrasts, whatever at static or pulsating status at gantry rotation time of 0.8 s and 1.0 s. It therefore can be effectively used in differentiating lesions from normal issues.