Zeitschrift für Adipositas- und Gewichtsverlusttherapie

Abstrakt

Emerging Pharmacotherapies to Fight Obesity and Related Disorders

Teodora Handjieva-Darlenska, Nadka Boyadjieva and Kaloyan Takov

Obesity is a chronic disease, characterized by an accumulation of excess adipose tissue and associated with an increased risk for cardio-vascular diseases and mortality. Weight loss of a 5-10% prevents or tempers the severity of many obesity-related morbidities. The current therapy of obesity comprises diet, increased physical activity, and pharmacotherapy. At the moment, the only approved drug for treatment of obesity in the European Union is Orlistat. This paper covers the latest research in the field with emphasis on the modulation of the different physiological systems and peptides in the regulation of appetite and metabolism through drugs as well as new drugs to treat diabetes type 2 and obesity. Furthermore, the authors show own data and results on the treatment of obesity in animal models and humans.