Internationale Zeitschrift für Forschung und Entwicklung in Pharmazie und Biowissenschaften

Abstrakt

EVALUATION OF SPERMICIDAL ACTIVITY OF AQUEOUS ROOT POWDER EXTRACT OF BUTEA MONOSPERMA (FAMILY: FABACEAE)

Kanakam Vijayabhaskar, Gugloth himabindu

This study was designed to assess the spermicidal property of aqueous extract of Butea monosperma root powder. We applied different concentrations of the extract and determined the effect on sperm motility using the in vitro immobilization assay. The result showed that at 160 mg/ml, there was an instant immobilization of all the spermatozoa on application of the extract. At a concentration of 80 mg/ml, the sperm motility were
8.20 ±0.10, 8.80 ± 0.51 , 9.63 ± 0.15, 9.50 ±0.28, 9.34 ± 0.44 , 9.17 ± 0.41 at 0, 15, 30, 60, 120 and 180 seconds respectively. Similarly, at 40 mg/ml, 20 mg/ml and 10 mg/ml, reduced sperm motility in a concentration - and time- dependent manner was observed. In conclusion, this Study shows that the crude extract of Butea monosperma root powder possesses spermicidal activity.