Biotechnologie und Biomaterialien

Abstrakt

In Vitro Study of Photocurable Embolization Agent for Cerebral Aneurysms

Ayaka Ishikawa, Yasuhide Nakayama and Nobuaki Kambe

The use of liquid embolic agents for the endovascular treatment of cerebral aneurysms has been reported in the neurosurgical literature. A major limitation of these agents is their relatively poor control of hardening ability. In this study, the technical feasibility of a novel gelatin-based photocurable liquid agent for embolization of cerebral aneurysms was evaluated using an experimental aneurysm model. The embolic agent used in this study was an aqueous mixture of photocurable gelatin (gelatin partially derivatized with eosin; 20 wt%; eosin content: 2.8 per gelatin molecule) and polyamine (a polymer of N,N -dimethylaminopropylacrylamide; 5 wt%). Because of its appropriate viscosity at 37 ⁰ C (206 ± 45 mPa•s), the agent could be delivered into the sac of a glass aneurysm model (internal diameter: 3 mm at parent artery part; 5 mm at aneurysm part) by using through a 6 French (Fr)-delivery catheter under the inflation of a balloon catheter at the neck of the aneurysmal sac. After photo irradiation for 40 seconds, the neck of the aneurysm was capped with hydrogel converted from the agent (100%, n=5). Because the colored water was distributed evenly in only a parent tube, complete embolization was observed. Thus, this photocurable agent has potential to be used for the embolization of cerebral aneurysms.