Zeitschrift für Schwangerschaft und Kindergesundheit

Abstrakt

Predictive Value of the TSH/FT4 Ratio in Women with Suspected PE or GH

Megumi Fudaba, Kazuharu Tanaka, Atsushi Matuski, Maya Komori, Takako Matsuki, Mie Tahara, Sachiyo Nishimoto, Koji Kajitani, Hiroaki Nakamura and Osamu Nakamoto

Objective: In the present study, we aimed to examine whether the TSH/FT4 ratio after the second trimester can predict the prevalence of preeclampsia (PE) or gestational hypertension (GH).

Study design: Retrospective case-control study.

Methods: We collected TSH and FT4 serum levels after the second trimester in 133 pregnant women with suspected PE or GH. Participants were divided into 2 groups, the PE+GH group and the non-PE+GH group and conducted the retrospective study for the two groups to evaluate the background and the prevalence of PE or GH were retrospectively evaluated.

Results: Among the participants in the PE+GH group, mean age, body mass index (BMI) at no pregnancy and BMI at delivery were 34.5 ± 6.7 years, 22.3 ± 3.9 kg/m² and 26.0 ± 4.0 kg/m², respectively. Among the participants in the non-PE+GH group, mean age, BMI at no pregnancy and BMI at delivery were 32.9 ± 5.5 years, 22.5 ± 4.8 kg/m² and 26.1 ± 4.4 kg/m², respectively. There were no significant differences observed between the two groups. The cutoff point of the TSH/FT4 ratio was 1.9 (sensitivity 0.45, specificity 0.81), which was derived from the receiver operating characteristic curve. The adjusted odds ratio of PE or GH prevalence was 3.60 (95% CI: 1.62-8.02).

Conclusion: The TSH/FT4 ratio after the second trimester may aid in the prediction of PE or GH prevalence.