Traditionelle Medizin und klinische Naturheilkunde

Abstrakt

Pro-angiogenic and Angiostatic Compounds from Terrestrial and Marine Sources

Pankaj G

The formation of new blood vessels out of pre-existing capillaries or angiogenesis is a sequence of events that is of key importance in a broad array of physiologic and pathologic processes. In several diseases, excessive angiogenesis is a part of the pathology such as cancer (both solid and hematologic tumors), cardiovascular disease (atherosclerosis), chronic inflammation (rheumatoid arthritis, Crohn’s disease), diabetes (proliferative diabetic retinopathy), neovascular wet age related macular degeneration, retinopathy of prematurity, psoriasis, andAIDS complications. These diseases may benefit from the therapeutic inhibition of angiogenesis. There has been a substantial progress made in research on natural products possessing several therapeutic actions as a result of which they have attracted attention of scientists, the world over and has profoundly influenced the course of discovery from traditional remedies. The present review entails such natural products from terrestrial and marine sources that have exhibited pro-angiogenic or antiangiogenic effects and offer subsequent potential for the development of novel pharmacological agents in the near future.