Toxikologie: Open Access

Abstrakt

Short Communication on Phototoxicity Assessment: Evaluation of Skin Phototoxicity Study Using SD Rats by Transdermal and Oral Administration

Yutaka Yonezawa, Kazuto Hashimoto, Hiroaki Nejishima and Haruko Ogawa

Guinea pigs are the most frequently used animals in phototoxicity studies. However, general toxicity studies most often use Sprague-Dawley (SD) rats. To shortening of the study period and to reduce the number of animals needed for drug development, we examined whether skin phototoxicity studies could be performed using SD rats. Drugs that had previously been shown to have phototoxic potential and known phototoxic compounds were administered transdermally and orally to guinea pigs and SD rats. After administration, the animals were irradiated with UV-A and UV-B. In the result, the concordance rate of guinea pigs and SD rats was 100% in the transdermal administration study and 85% in the oral administration study. This study demonstrated that phototoxicity studies using SD rats have the same potential to detect phototoxic compounds as studies using guinea pigs.