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The Breakdown of Veterinary Drugs is Influenced by the Redox Potentials of Anaerobic Pig Slurry

Susanne Jones

The fate of veterinary medications in the environment has drawn increasing attention since they are routinely employed in intensive livestock husbandry. Even though this knowledge is crucial for a more thorough assessment of environmental risk, pig slurry qualities have rarely been examined in research studies in relation to the fate of veterinary medications. The amount of antibiotics added to the soil and the results of the risk assessment may change depending on how quickly manure degrades. The purpose of this study was to find out if the degradation rates of acetyl-salicylic acid, ceftiofur, florfenicol, oxytetracycline, sulfamethoxazole, and tylosin were influenced by commonly reported redox potentials. Redox potentials of 100 mV (reduced), 250 mV (anaerobic), and 400 mV were used (very anaerobic). There was found to be a compound-specific connection. The degradation of ceftiofur, florfenicol, oxytetracycline, and sulfamethoxazole was inhibited under reduced conditions over that of very anaerobic conditions, with the corresponding DT50 values being 0.7-1.84 h, 1.35-3.61 h, 22.2-49.8 h, 131-211 h, and 35.4-94 h. This was a compound-specific relationship that was Tylosin, however, was discovered to decay more quickly under decreased circumstances than under extremely anaerobic (DT50 6.88–19.4 h). In order to improve the environmental risk assessment of veterinary medicines, the research presented here shows the significance of redox potential on degradation rates and suggests that redox control needs to be strict and standardized.