Zeitschrift für klinische und experimentelle Pathologie

Abstrakt

A Case of Vas Deferens Lesion with Features of Vasitis Nodosa and Mesothelial Proliferationc

Wenyi Luo, Beth Raju

Background: Vasitis nodosa is a nodular lesion within the vas deferens that is characterized by a benign glandular proliferation of the vas deferens epithelium mixed with sperm and chronic inflammation. It is considered a reactivecondition caused by increased intraluminal pressure. Problems in diagnosis can arise when atypical morphologic features are present.

Case presentation: A 25-year old African American male status post vasectomy was diagnosed with obstructive azoospermia and elected to undergo a vasovasostomy. The morphology of the resected specimen was consistent with vasitis nodosa, but the proliferative epithelial cells also demonstrated the phenotype of mesothelium by immunohistochemistry.

Conclusion: This is the first reported case of vas deferens lesion with both features of vasitis nodosa and mesothelial proliferation, and it may give insight into the cellular origin of vasitis nodosa.