ISSN: 2161-0681

Zeitschrift für klinische und experimentelle Pathologie

Offener Zugang
English Spanish Chinese Russian French Japanese Portuguese Hindi Telugu Tamil

Unsere Gruppe organisiert über 3000 globale Konferenzreihen Jährliche Veranstaltungen in den USA, Europa und anderen Ländern. Asien mit Unterstützung von 1000 weiteren wissenschaftlichen Gesellschaften und veröffentlicht über 700 Open Access Zeitschriften, die über 50.000 bedeutende Persönlichkeiten und renommierte Wissenschaftler als Redaktionsmitglieder enthalten.

Open-Access-Zeitschriften gewinnen mehr Leser und Zitierungen
700 Zeitschriften und 15.000.000 Leser Jede Zeitschrift erhält mehr als 25.000 Leser

Veröffentlichungsrichtlinien und Ethik
Indiziert in
  • Index Copernicus
  • Google Scholar
  • Sherpa Romeo
  • Öffnen Sie das J-Tor
  • Genamics JournalSeek
  • JournalTOCs
  • Ulrichs Zeitschriftenverzeichnis
  • RefSeek
  • Hamdard-Universität
  • EBSCO AZ
  • OCLC – WorldCat
  • Publons
  • Genfer Stiftung für medizinische Ausbildung und Forschung
  • Euro-Pub
  • ICMJE
Mehr sehen
Nützliche Links
Open-Access-Zeitschriften
Mehr sehen
Teile diese Seite

Abstrakt

Inter-Threshold Agreement for Infarct Lesion Volume According to the Apparent Diffusion Coefficient

Arnaud Bufacchi, F Zhu, B Gory, G Hossu, E Micard, R Anxionnat, S Bracard, B Chen

Background and purpose: ADC threshold-based computer mapping provide pertinent ischemic stroke volume. Indeed, pre-treatment lesional volume appears to be an independent predictor for functional outcome in AIS with proximal intracranial large vessel occlusion.

The aim of this study is to determine volumetric agreement between Olea Sphere® and our homemade software named Strike® using three different ADC thresholds (600, 615, 620 mm2/s) to evaluate the influence on functional outcomes of patients with AIS treated by Mechanical Thrombectomy Combined with Intravenous Thrombolysis (IVTMT).

Methods: 101 patients from THRACE (Mechanical thrombectomy after intravenous alteplase versus alteplase alone after stroke) were included. AIS were segmented from Olea Sphere® with an ADC threshold of 600 × 10-6 mm2/s, and with Strike® with 615 × 10-6 mm2/s and 620 × 10-6 mm2/s.

The primary study outcome was to compare the AIS’s mean volumes obtained with these different ADC thresholds. Secondary outcome was to determinate if this AIS volumes can be predicting functional prognosis which favourable outcomes: mRS=0-2 at 3 months.

Result: AIS’s volumes differences for each ADC thresholds were: Sphere® (600 mm2/s) and Strike® (615 mm2/s)=6.1200 (p-value: 0.6405), Sphere (600 mm2/s) and Strike® (620 mm2/s)=-11.0476 (p=0.0776) and Strike® (615 mm2/s) and Strike® (620 mm2/s)=-4.9276 (p=0.9562). The observed association between ADC 600 mm2/s (Sphere®) and functional outcome remained significant (p=0.0448). ADC 615 mm2/s and ADC 620 mm2/s remained not statistically significant (Respectively p=0.0987 and p=0.0692).

Conclusion: Several currently ADC thresholds for the measurement of AIS volume estimation are highly comparable and can be helpful before therapeutic decisions. However, some discrepancies can be found when correlating to the functional prognosis according to the ADC threshold for patients treated by Mechanical Thrombectomy Combined with Intravenous Thrombolysis (IVTMT).

Zeitschriften nach Themen
Klinische und medizinische Fachzeitschriften