Zeitschrift für Pharmakokinetik und experimentelle Therapeutik

Abstrakt

The solubility measurements of crystallized Ibuprofen at low

Afrina Afrose,

The objective of this study was to determine the effect of five pharmaceutically used excipients e.g. L-lactose, hydroxy propyl methyl cellulose (HPMC)1 , leucine, D-mannitol and Pluronic F127 (Pl F127) on the ibuprofen (Ibu) solubility in water (W) - ethanol (E) co-solvent systems. The solubility was measured in water (W) - ethanol (E) mixtures from 0 to 50% w/w ethanol at 10, 25 and 40 °C by the dissolution method using UV spectrophotometry. The Ibu solubility without excipients in water (zero ethanol) was low (~ 50 ppm); however, increased near exponentially with increasing ethanol content.